An Attack on Self Tissues

When the immune system mistakes self tissues for nonself and mounts an inappropriate attack, the result is an autoimmune disease.
There are many different autoimmune diseases. Some examples are Wegener's granulomatosis, multiple sclerosis, type 1 diabetes mellitus, and rheumatoid arthritis.

Autoimmune diseases can each affect the body in different ways. For instance, the autoimmune reaction is directed against the brain in multiple sclerosis and the gut in Crohn's disease. In other diseases, such as systemic lupus erythematosus (lupus), affected tissues and organs may vary among individuals with the same disease.

 

The Body's First Line of Defense

The immune system is a complex of organs--highly specialized cells and even a circulatory system separate from blood vessels--all of which work together to clear infection from the body.

The organs of the immune system, positioned throughout the body, are called lymphoid organs. The word "lymph" in Greek means a pure, clear stream--an appropriate description considering its appearance and purpose.

 
Diagram: Lymphatic vessels
Lymphatic vessels form a circulatory system that operates in close partnership with blood circulation.
Lymphatic vessels and lymph nodes are the parts of the special circulatory system that carries lymph, a transparent fluid containing white blood cells, chiefly lymphocytes.

 
Lymph bathes the tissues of the body, and the lymphatic vessels collect and move it eventually back into the blood circulation. Lymph nodes dot the network of lymphatic vessels and provide meeting grounds for the immune system cells that defend against invaders. The spleen, at the upper left of the abdomen, is also a staging ground and a place where immune system cells confront foreign microbes.   Diagram: Immune system organs
Organs and tissues of the immune system dot the body in a protective network of barriers to infection.

Pockets of lymphoid tissue are in many other locations throughout the body, such as the bone marrow and thymus. Tonsils, adenoids, Peyer's patches, and the appendix are also lymphoid tissues.

Both immune cells and foreign molecules enter the lymph nodes via blood vessels or lymphatic vessels. All immune cells exit the lymphatic system and eventually return to the bloodstream. Once in the bloodstream, lymphocytes are transported to tissues throughout the body, where they act as sentries on the lookout for foreign antigens.

How the Immune System Works
Cells that will grow into the many types of more specialized cells that circulate throughout the immune system are produced in the bone marrow. This nutrient-rich, spongy tissue is found in the center shafts of certain long, flat bones of the body, such as the bones of the pelvis. The cells most relevant for understanding vaccines are the lymphocytes, numbering close to one trillion.

The two major classes of lymphocytes are B cells, which grow to maturity in the bone marrow, and T cells, which mature in the thymus, high in the chest behind the breastbone.

 

B cells produce antibodies that circulate in the blood and lymph streams and attach to foreign antigens to mark them for destruction by other immune cells.

B cells are part of what is known as antibody-mediated or humoral immunity, so called because the antibodies circulate in blood and lymph, which the ancient Greeks called, the body's "humors."

  B cells

B cells become plasma cells, which produce antibodies when a foreign antigen triggers the immune response.

Certain T cells, which also patrol the blood and lymph for foreign invaders, can do more than mark the antigens; they attack and destroy diseased cells they recognize as foreign. T lymphocytes are responsible for cell-mediated immunity (or cellular immunity). T cells also orchestrate, regulate and coordinate the overall immune response. T cells depend on unique cell surface molecules called the major histocompatibility complex (MHC) to help them recognize antigen fragments.


Antigens
Antibodies produced by cells of the immune system recognize foreign antigens and mark them for destruction.
Antibodies

The antibodies that B cells produce are basic templates with a special region that is highly specific to target a given antigen. Much like a car coming off a production line, the antibody's frame remains constant, but through chemical and cellular messages, the immune system selects a green sedan, a red convertible or a white truck to combat this particular invader.

However, in contrast to cars, the variety of antibodies is very large. Different antibodies are destined for different purposes. Some coat the foreign invaders to make them attractive to the circulating scavenger cells, phagocytes, that will engulf an unwelcome microbe.

When some antibodies combine with antigens, they activate a cascade of nine proteins, known as complement, that have been circulating in inactive form in the blood. Complement forms a partnership with antibodies, once they have reacted with antigen, to help destroy foreign invaders and remove them from the body. Still other types of antibodies block viruses from entering cells.

T Cells
T cells have two major roles in immune defense. Regulatory T cells are essential for orchestrating the response of an elaborate system of different types of immune cells.

 

Helper T cells, for example, also known as CD4 positive T cells (CD4+ T cells), alert B cells to start making antibodies; they also can activate other T cells and immune system scavenger cells called macrophages and influence which type of antibody is produced.

Certain T cells, called CD8 positive T cells (CD8+ T cells), can become killer cells that attack and destroy infected cells. The killer T cells are also called cytotoxic T cells or CTLs (cytotoxic lymphocytes).

T cells
T lymphocytes become CD4+ or helper T cells, or they can become CD8+ cells, which in turn can become killer T cells, also called cytotoxic T cells.

Immune system process
Activation of helper T cells

Activation_T cells

After it engulfs and processes an antigen, the macrophage displays the antigen fragments combined with a Class II MHC protein on the macrophage cell surface. The antigen-protein combination attracts a helper T cell, and promotes its activation.

Activation of cytotoxic T cells
Activation

After a macrophage engulfs and processes an antigen, the macrophage displays the antigen fragments combined with a Class I MHC protein on the macrophage cell surface. A receptor on a circulating, resting cytotoxic T cell recognizes the antigen-protein complex and binds to it. The binding process and a helper T cell activate the cytotoxic T cell so that it can attack and destroy the diseased cell.

Activation of B cells to make antibody
Activation of B Cells to make antibody

A B cell uses one of its receptors to bind to its matching antigen, which the B cell engulfs and processes. The B cell then displays a piece of the antigen, bound to a Class II MHC protein, on the cell surface. This whole complex then binds to an activated helper T cell. This binding process stimulates the transformation of the B cell into an antibody-secreting plasma cell.

1-26-05 repost

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